click here for details           Combigan  (U.S.N.L.M.)
Dosing 1 drop bid, 12 hours apart
Chem Specs brimonidine tartrate 0.2% / timolol maleate 0.5%
Quantities 5 ml in 10 ml bottle,   10 ml in 10 ml bottle
Cost 187.00/5ml
Class Relatively selective alpha-2 adrenergic receptor agonist / beta blocker
Action Brimonidine reduces aqueous production and increases uveoscleral outflow. Timolol
reduces aqueous formation by blocking beta2 receptors on nonpigmented ciliary epithelium
Usage Adjunctive or replacement therapy for the reduction of IOP.
(e.g. commonly replaces prostaglandin for inflammatory glaucomas).
About 5% incidence of allergic conjunctivitis (vs 30% with generic brimonidine).
14% discontinuation from all adverse effects.
Contraindications Bronchial asthma, sinus bradycardia, COPD, overt cardiac failure, cardiogenic
shock, atrioventricular block and hypersensitivity to any of the product contents.
Pediatric use > age 2
Pregnancy Category C
0.005% BAK preserved.
22% average IOP reduction.