click here for details           Natacyn  (U.S.N.L.M.)
Dosing/ keratitis 1 drop q1-2 hr x 3-4 days, then 1 drop 6-8 times/day. Continue 14 to 21 days.
For blepharitis and conjunctivitis reduce initial dose to 4 to 6 drops per day.
Consider supplementing with oral voriconazole.1
Chem Specs natamycin 5%
Quantities 15ml glass bottle with dropper
Cost 350.00
Class Polyene amphoteric macrolide antifungal
Action Alters fungal cell membrane permeability by binding with membrane sterols.
Activity Active against a variety of yeast and filamentous fungi including Candida,
Aspergillus, Cephalosporium, and Fusarium.
Usage Indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis
caused by susceptible organisms including Fusarium solani keratitis.
Contraindications Hypersensitivity to natamycin any Natacyn components.
Pediatric use Safety and effectiveness in pediatric patients have not been established.
Pregnancy Category C
Drug is viscous, irritating, and has poor penetration . Alternatives are orals voriconazole (Vfend)
and fluconazole (Diflucan) or injected Amphotericin B (Fungizone, Bristol-Myers Squibb).
1. Rose-Nussbaumer JR, Am Acad Oph, Chicago, Oct. 14-18, 2016; Fusarium subgroup may show better response with supplementation.