Natacyn  (U.S.N.L.M.)
Dosing/ keratitis 1 drop every hour while awake, every 2 hours at night x 3-4 days, then
1 drop 6-8 times/day. Continue 14 to 21 days.
For blepharitis and conjunctivitis reduce initial dose to 4 to 6 drops per day.
Chem Specs natamycin 5%
Quantities 15ml glass bottle with dropper
Cost 479.00
Class Polyene amphoteric macrolide antifungal
Action Alters fungal cell membrane permeability by binding with membrane sterols.
Activity Active against a variety of yeast and filamentous fungi including Candida,
Aspergillus, Cephalosporium, and Fusarium.
Active against a variety of yeast and filamentous fungi including Candida, Aspergillus, Cephalosporium, and Fusarium.
Usage Indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis
caused by susceptible organisms including Fusarium solani keratitis. Indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.
Contraindications Hypersensitivity to natamycin any Natacyn components.
Pediatric use Safety and effectiveness in pediatric patients have not been established.
Pregnancy Neither human nor animal reproduction studies have not been conducted with natamycin.
Natamyin is a common food addative (in the U.S.).
Drug is viscous, irritating, and has poor penetration . Alternatives include 1% voriconazole
drops prepared from powder and orals voriconazole (Vfend)1 and fluconazole (Diflucan) or
injected Amphotericin B (Fungizone, Bristol-Myers Squibb).
Drug is viscous, irritating, and has poor penetration . Alternatives include 1% voriconazole drops prepared from powder and orals voriconazole (Vfend)1 and fluconazole (Diflucan) or injected Amphotericin B (Fungizone, Bristol-Myers Squibb).
1. Rose-Nussbaumer JR, Am Acad Oph, Chicago, Oct. 14-18, 2016; Fusarium subgroup may show better response with supplementation.
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