click here for details           Neptazane  (U.S.N.L.M.)
Dosing 50mg po single dose for emergency IOP reduction
(See package insert for other dosing.)
Chem Specs methazolamide
Quantities 25,  50mg tab
Cost 156.00/30tab/50mg (generic)
Class carbonic anhydrase inhibitor
Action Inhibition of carbonic anhydrase II in the ciliary processes presumably slows the
formation of bicarbonate with subsequent reduction in sodium and fluid transport.
Usage Indicated in the treatment of chronic open-angle glaucoma, secondary
glaucoma, and preoperatively in acute angle-closure glaucoma
Sulfonamides can cause hypersensitivity fatalities, Stevens-Johnson syndrome,
toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic
anemia and other blood dyscrasias.
Contraindications Low sodium and/or potassium serum levels, marked kidney or liver disease
or dysfunction, adrenal gland failure, and hyperchloremic acidosis. In patients
with cirrhosis, use may precipitate the development of hepatic encephalopathy.
Hypersensitivity to any component of this product.
Pediatric use Safety and effectiveness in children not established.
Pregnancy Category C
Anorexia, tachypnea, lethargy, coma and death have been reported with
concomitant use of high-dose aspirin and carbonic anhydrase inhibitors.