click here for details           Polytrim  (U.S.N.L.M.)
Dosing/ Conjunctivitis 1 drop q 3hr for 7 to 10 days.
Chem Specs polymyxin B sulfate 10,000 units/mL; trimethoprim sulfate equiv 1 mg/mL.
Quantities 10ml
Cost 4.00 generic
Class Polypeptide / Sulfonamide
Action Trimethoprim - prevents bacterial folic acid synthesis (inhibits bacterial DNA synthesis).
Polymyxin B - surfactant acts on phospholipids of bacterial cell membrane.
Activity Active against a wide variety of aerobic gram-positive and gram-negative
ophthalmic pathogens including Staph aureus and Pseudomonas aeruginosa.
Fewer than 10% of S. aureus and methicillin-resistant S. aureus resistant to trimethoprim (2018).
Usage Indicated for surface ocular bacterial infections, including acute
conjunctivitis, and blepharoconjunctivitis.
Excellent coverage of Haemophilus influenzae and Streptococcus
pneumoniae makes Polytrim popular in pediatric usage.
Contraindications Known hypersensitivity to components.
Pediatric use > 2 months
Pregnancy Category C
Useful as adjunctive therapy when fluoroquinolone resistance is suspected.