click here for details           Tim-Brim-Dor-Lat™PF   (U.S.N.L.M.)
Dosing q.p.m. This is the PM arm of the "Triple/Quad, AM - PM pairing".
It is intended for use in unison with the triple "AM combination"1.
Chem Specs timolol 0.5%,  brimonidine 0.15%,   dorzolamide 2.0%,   latanoprost 0.005%
Quantities 5ml,
Cost 138.00 (69.00 per month)
Class timolol:           Non-selective beta-adrenergic receptor blocker.
brimonidine:   Relatively selective alpha-2 agonist.
dorzolamide:   Carbonic anhydrase inhibitor
latanoprost:    Prostaglandin analog (prodrug)
Usage The preservative-free, single container preparation can reduce surface toxicity and
enhance compliance.
Contraindications
timolol

Bronchial asthma, a history of bronchial asthma, COPD, sinus bradycardia,
second or third degree atrioventricular block, overt cardiac failure, cardiogenic shock.
Numerous additional cautions listed here.

brimonidine

neonates and infants (under the age of 2 years)
Vascular insufficiency cautions listed here.

dorzolamide

Sulfonamide hypersensitivity.

latanoprost

Latanoprost hypersensitivity
Pediatric use Safety and effectiveness in pediatric patients have not been established.
Pregnancy Category B  (brimonidine)
1. The "AM combination" Tim-Brim-Dor™ is similar but lacks latanaprost (daily dosing).
Bottle with one way valve requires refrigeration.
Individual drugs are FDA approved but the combination is not.