click here for details           Trusopt  (U.S.N.L.M.)
Dosing 1 drop tid (monotherapy)     bid (additive therapy)
Chem Specs dorzolamide 2.0%
Quantities 5, 10ml
Cost 23.00/5ml
Class carbonic anhydrase inhibitor
Action Inhibition of carbonic anhydrase II in the ciliary processes presumably slows the
formation of bicarbonate with subsequent reduction in sodium and fluid transport.
Usage Indicated for elevated IOP of ocular hypertension or open-angle glaucoma.
Trusopt is a sulfonamide and is absorbed systemically. Fatalities, Stevens-Johnson
syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis,
aplastic anemia, and other blood dyscrasias have occurred.
Contraindications Hypersensitivity to sulfonamide or any other component of this product. Concomitant
administration with oral carbonic anhydrase inhibitors is not recommended.
Pediatric use Safety and IOP-lowering effects have been demonstrated in pediatric patients.
Pregnancy Category C
BAK preserved.
CAI's exert 70% of waking effect during sleep, prostaglandins 50% and timolol almost none.
Bitter taste sometimes encountered.