| Tylenol #3 (U.S.N.L.M.) | ||
|---|---|---|
| Dosing: (Mild to moderate pain of iritis, corneal abrasion) |
1 or 2 tabs every 4 to 6 hrs. Maximum daily dose of 360mg codein and 4,000 mg tylenol. | |
| Chem Specs | 30mg codeine and 300mg acetaminophen | |
| Quantities | Often prescribed on 24hr basis with no refills. (e.g. "12 (twelve) tablets)") | |
| Cost | 15.72 for 20 tablets generic | |
| Class | Opium alkaloid narcotic (codeine). Aniline analgesic (acetaminophen). | |
| Action | Synergistic pain relief. Each drug acting on a separate area of the nervous system. | |
| Usage | Schedule 3 narcotic used for mild to moderate pain relief. | |
| Caution | Acetaminophen related risk of acute liver failure in patients with underlying liver disease and alcohol use. Alcohol and other CNS depressants may cause additive CNS depression. |
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| Contraindications | Hypersensitivity to codeine or acetaminophen | |
| Pediatric use | Safety and effectiveness below age 18 not established. | |
| Pregnancy | Category C. Embryo resorption and delayed ossification associated with toxic dose in rats. | |
| Acetamenophen overdose is a common cause of liver failure. Codeine ultra-rapid metabolizers (CYP2D6*2x2 genotype) subject to overdose. |
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| Significant sedation, GI disturbance and constipation are common side effects. Consider Empirin when inflammatory control is desired. |
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