click here for details            Ultracet  (U.S.N.L.M.)
Dosing: (Iritis, corneal abrasion.) 2 tablets every 4 to 6 hours, not to exceed 8 tablets daily.
Chem Specs 37.5 mg of tramadol hydrochloride and 325 mg of acetaminophen.
Quantities Not approved for use for more than 5 days. Often prescribed on 24 or 48hr basis
with no refills. (e.g. "16 (sixteen) tablets").
Cost 13.00 / 20 tablets    generic
Class Synthetic ÎĽ-opioid receptor agonist (tramadol), Aniline analgesic (acetaminophen)
Tramadol also acts as a weak serotonin–norepinephrine reuptake inhibitor.
Action Synergistic pain relief. Each drug acting on a separate area of the nervous system.
Usage Moderate to moderatly severe pain relief.
Caution Acetaminophen related risk of acute liver failure in patients with underlying liver disease and
alcohol use. Alcohol and other CNS depressants may cause additive CNS depression. See

package insert information re hepatic and renal impairment, the elderly, and "ultra fast metabolizers".
Contraindications Hypersensitivity to tramadol or acetaminophen. Patients with significant respiratory
depression, severe bronchial asthma, gastrointestinal obstruction, using of monoamine
oxidase inhibitors (MAOIs) or use within the previous 14 days.
Pediatric use Contraindicated for children under 12.
Pregnancy Category C
Tramadol acts on the opioid receptors through its major active metabolite desmetramadol, which
has as much as 700-fold higher receptor affinity than tramadol. Desmetramadol activates opioid
receptors with intrinsic activity similar to morphine.
Schedule IV.
Pain relief usually occurs within an hour with immediate-release formulation.