click here for details           Vancomycin   (U.S.N.L.M.)
Dosing/ Keratitis Every 30 minutes for 3 hours, then qhr for first 24 hours, taper gradually on improvement.
(If non central consider besifloxacin .)
Chem Specs vancomycin 5%
Quantities 500mg reconstituted with 10ml sterile water.
Cost 286.00 U.S.   (5.00 to 10.00 elsewhere)
Class Glycopeptide
Action Binds to amino acids necessary for bacterial cell wall synthesis and alters
bacterial cell membrane permeability.
Activity Narrow spectrum antibiotic. Bactericidal against certain gram-positive
organisms. Not active against gram-negative bacilli, mycobacteria, or fungi.
Usage Indicated for the treatment of serious or severe infections caused by susceptible
strains of methicillin-resistant staphylococci (MRSA) and penicillin-resistant streptococci.
Contraindications Known hypersensitivity to vancomycin.
Pediatric use Systemically used in infants > 7 days.
Pregnancy Category C
The aqueous solution is unstable but may be kept refrigerated for 4 days (96hr).
Consider concomitant cycloplegia for anterior uveitis. Fortified Tobramycin is used for gram-negative coverage.
5% solution stings on administration. Some advocate 2.5% which is thought to be adequate.1

1. Romanowski EG, Romanowski JE, Shanks RMQ, et al. Cornea. October 24, 2019.