Oxervate  (U.S.N.L.M.)
Dosing 1 drop 6 times a day at 2 hour intervals for eight weeks
Chem Specs cenegermin-bkbj 0.002%
Quantities Weekly Vial Carton (7 multiple-dose vials). Delivery System Kit (7 vial adapters, 42 pipettes,
42 sterile disinfectant wipes, a Dose Recording Card).
Cost $29,000   (8 week supply)
Class Neurotrophin. Recombinant nerve growth factor (NGF).
Action Replicates action of endogenous NGF controlling neurotransmitter and neuropeptide synthesis.
Usage Indicated for the treatment of neurotrophic keratitis.
NGF influences the neuronal plasticity in the adult nervous system affecting innervation
density, axonal terminal sprouting, and dendrite arborization.
Contraindications None
Pediatric use Safety and effectiveness established in pediatric patients age 2 and older.
Pregnancy Administration to pregnant rats or rabbits during organogenesis did not produce adverse fetal
effects at clinically relevant doses.
Contact lenses should be removed for 15 minutes when applying Oxervate.
Included instructions describe a 19 step application procedure to be followed 6 times a day.
    N.L.M. DailyMed page for Oxervate