Atropine  (cyloplegia)
Dosing (cycloplegia) 1 drop 0.5% to 1% bid for 1 or 2 days before examination.
(Consider cyclopentolate 1% administered 30 min before refraction.)
Dosing  (uveitis/iritis) 1 or 2 drops up to 4 times daily   (1% bid typically)
Chem Specs atropine sulfate 1%   Common prepared concentrations: 0.01%, 0.25%, 0.50%
Quantities 2,5,15ml
Cost 64.88 5ml generic 1% .
Class anticholinergic
Action Competitive antagonist for the muscarinic acetylcholine receptor.
Usage Indicated for cycloplegic refraction or for pupil dilation in acute iritis and uveitis.
Used off label to prevent myopic progression.
Warnings Increased susceptibility in infants, young children, and in children with blond hair, blue eyes, Down's
syndrome, spastic paralysis, or brain damage. Ointment form thought to reduce systemic absorption.
Contraindications Primary glaucoma or a predisposition toward narrow angle glaucoma. Iris lens synechiae.
Pediatric patients who have previously had a severe systemic reaction to atropine. The elderly
and others where undiagnosed glaucoma or excessive pressure in the eye may be present.
Hypersensitivity to atropine or product contents.
Pediatric use Not recommended under 3 months. Limit to 1 drop per eye per day under 3 years.
Pregnancy Category C. It is not known whether topically administered atropine sulfate can cause fetal harm.
Peak mydriasis 30-40 min. Peak cycloplegia 1-2 hrs. Recovery 6-12 days.
Nasolacrimal pressure recommended.
Systemic anticholinergics may be associated with increased risk of dementia.1
1. Risacher, McDonald, Tallman, et al. JAMA April 18, 2016.     N.L.M. DailyMed page for Atropine          PDR page for Atropine