OSRX® Prepared Atropine

          OSRX® Prepared Atropine  (U.S.N.L.M.)
(Myopia prevention) 1 or 2 drops 0.05%1 qhs
(0.5% starting dose used weekly may be appropriate for high rates of progression.2)
Chem Specs atropine sulfate 0.01%, 0.025%, 0.05%
Quantities 3.5ml
Cost 45.00  OSRX®
Class anticholinergic
Action Competitive antagonist for the muscarinic acetylcholine receptor.
Myopia Prevention Reduction in myopia progression is age and dose dependent. (The younger the age the
lower the response to given dosage.)3 The 0.05% concentration provides about twice the
protective effect as the 0.01% solution1.    Rebound after cessation can be avoided with
a  taper  regardless  of dosage used4.    Although  slight  mydriasis  is  present  with  low
dosages5(0.01% to 0.05%),  problematic photophobia and cycloplegia is generally absent.
With higher concentrations (0.5% or 1%)  these side effects should be addressed with
progressive and photochromic lenses.
Increased susceptibility in infants, young children, and in children with blond hair, blue eyes,
Down's syndrome, spastic paralysis, or brain damage.
Contraindications Predisposition toward narrow angle glaucoma. Pediatric patients who have previously had
a severe systemic reaction to atropine. Hypersensitivity to atropine or product contents.
Pediatric use > 3 months
Pregnancy Category C
0.01% BAK
Systemic anticholinergics may be associated with increased risk of dementia.6
    N.L.M. DailyMed page for Prepared Atropine          PDR page for Prepared Atropine 1. Jason C. Yam, et.al., LAMP II December 2019
2. Polling JR, Tan E, Driessen S, et al. Eye (Lond). 2020 Sep 21.
3. JAMA Ophthalmol; 2021 Jan 14; EPub Ahead of Print; J Wang, Y Li, DC Musch, et. al.
4. Zhu et. al., Efficacy and Safety of 1% Atropine... Int J Med Sci. 2020; 17(2): 176–181.
5. Joachimsen L, Böhringer D, Gross NJ, et al. Ophthalmol Ther. 2019 Jun 12.
6. Risacher, McDonald, Tallman, et al. JAMA April 18, 2016.