| Augmentin (U.S.N.L.M.) | |
|---|---|
| Dosing: (Dacryocystitis, Preseptal Cellulitis) |
Mild to Moderate: 250mg tid to 500mg bid(q12hr). Severe: 500mg tid to 875mg bid(q12hr). |
| Chem Specs | amoxicillin / clavulanate (β-lactamase inhibitor) |
| Quantities | Tablets(250, 500, 875mg), Chewable(125, 200, 250, 400mg), Suspension(125, 200, 250, 400mg). |
| Cost | 57.19/20/875mg generic |
| Class | moderate-spectrum ß-lactam antibiotic / ß-lactamase inhibitor |
| Action | Inhibits cross-linkage between the peptidoglycan polymer chains of bacterial cell wall. / Inhibits bacterial ß-lactamase enzyme. |
| Usage | Used against ß-lactamase producing strains of H. influenzae, M. catarrhalis, S. aureus, E. coli, Klebsiella spp as well as ampicillin-susceptible organisms particularly S. pneumoniae. |
| The q12hr regimen is preferred. 10 day course is typical. | |
| Contraindications | Allergy to any of the penicillins. or other ß-lactams. Previous cholestatic jaundice/hepatic dysfunction associated with Augmentin. |
| Pediatric use | Consult dosing tables and package insert warnings for children under 40kg. |
| Pregnancy | Category B. No animal evidence of teratogenic effects. |