| Cortisporin (U.S.N.L.M.) | |
|---|---|
| Dosing | One or two drops every 3 or 4 hours. |
| Chem Specs | neomycin sulfate (equivalent to 3.5 mg neomycin base), polymyxin B sulfate equivalent to 10,000 polymyxin B units, and hydrocortisone (1%) |
| Quantities | 7.5ml |
| Cost | 156.00 |
| Class | aminoglycoside / bactericidal peptid / steroid |
| Action | Neomycin binds to the 30S ribosome preventing protein synthesis. Polymyxin B is a cell membrane disruptor. Hydrocortisone (a.k.a. cortisol) inhibits phospholipase A (thus arachidonic acid metabolism). Neomycin binds to the 30S ribosome preventing protein synthesis. Polymyxin B is a cell membrane disruptor. Hydrocortisone (a.k.a. cortisol) inhibits phospholipase A (thus arachidonic acid metabolism). |
| Activity | Neomycin is active against Gram-negative aerobes and some anaerobic bacilli. Polymyxin B sulfate is active against Gram-negative species. Hydrocortisone is a weak short acting steroid. Neomycin sulfate and polymyxin B sulfate are active against Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterbacter, Neisseria , and Pseudomonas aeruginosa. |
| Usage | Indicated for ocular surface inflammation where risk of bacterial infection exists. |
| Neomycin is notable for its tendency to cause Type IV delayed hypersensitivity reaction. May cause ocular hypertension / glaucoma, and cataract with prolonged use. Monitor IOP if used for more than 10 days. |
|
| Contraindications | Contraindicated in most viral, mycobacterial, and fungal diseases of the eye. |
| Pediatric use | Safety and effectiveness not been established in pediatric patients. |
| Pregnancy | Category C. Steroids topically applied to animals in the human ocular dose are teratogenic. |
| "Cortisporin" is the brand name used for initial approval in 1975. It was sold to Monarch which discontinued its use in 2008. Now sold as a generic. Preserved with thimerosal 0.001%. "Cortisporin" is the brand name used for initial approval in 1975. It was sold to Monarch which discontinued its use in 2008. Now sold as a generic. Preserved with thimerosal 0.001%. |
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