| Durezol emulsion (U.S.N.L.M.) | |
|---|---|
| Dosing (post surgical) | 1 drop qid for 2 weeks beginning 24 hrs after surgery. Then bid for 1 week. Then taper. |
| Dosing (anterior uveitis) | 1 drop qid for 2 weeks, more often in the first 48 hours if necessary. Taper |
| Chem Specs | difluprednate 0.05% |
| Quantities | 5ml |
| Cost | 72.00 (generic) |
| Class | (difluorinated) corticosteroid. |
| Action | Anti-inflammatory |
| Usage | Used to treat inflammation and pain associated with ocular surgery and anterior uveitis. |
| May be dosed at about half the frequency as Pred Forte while achieving the same clinical efficacy. |
|
| Caution | Elevated IOP, fungal and bacterial overgrowth, cataract formation, globe perforation possible with long term use. |
| Contraindications | Most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis, vaccinia, and varicella, mycobacterial and fungal disease. Hypersensitivity to any of the ingredients of this preparation and to other corticosteroids. |
| Pediatric use | Safety and effectiveness in pediatric patients have not been established. |
| Pregnancy | Category C. Embryotoxic and teratogenic given subcutaneously to rabbits at 1 mcg/kg/day. |
| Excellent tissue penetration. Enhanced dose uniformity (no shaking required) and duration of action when compared to acetate suspensions, but higher risk of IOP increase. |