| Fortisite (503B compound) | |
|---|---|
| Dosing | q15min x 1hr, then qh 1st day then q1 or 2hr while awake till resolved. |
| Chem Specs | tobramycin 1.5% and vancomycin 5% |
| Quantities | 7ml |
| Cost | 299.00 |
| Class | Aminoglycoside / Glycopeptide |
| Action | Aminoglycoside prevents bacterial protein synthesis (binds to ribosome s30 or s50). Glycopeptide binds to cell wall amino acids altering bacterial cell membrane permeability. |
| Activity | Active against a wide variety of gram-negative and gram-positive bacteria including some penicillin-resistant, gentamicin-resistant and methicillin-resistant strains. |
| Usage | Indicated in the treatment of severe external infections of the eye and adnexa. |
| Aminoglycoside toxicity possible with pre-sensitized pts. or with extended use. | |
| Contraindications | Known hypersensitivity to any of its components. |
| Pediatric use | > 2 months |
| Pregnancy | No adequate and well-controlled studies in pregnant women. 3 animal studies have failed to demonstrate fetal risk with tobramycin. Animal reproduction studies have not been conducted with vancomycin. |
| refrigerate at 5°C for up to 180 days. |