| Rocklatan (U.S.N.L.M.) | |
|---|---|
| Dosing | qpm |
| Chem Specs | netarsudil 0.02%, latanoprost 0.005% |
| Quantities | 2.5ml, |
| Cost | 361.60 |
| Class |
netarsudil: Rho Kinase inhibitor. latanoprost: Prostaglandin F2α analogue (prodrug). |
| Usage | 30% reduction in IOP achieved in 60% of users. |
| Contraindications |
netarsudil Hypersensitivity to Xalantan or any other ingredient in the product.
latanoprost Latanoprost hypersensitivity
|
| Side Effects |
netarsudil
Mild conjunctival hyperemia occurs in 50% to 60%, but is consistently observed in only 10% and so is considered "well tolerated". Corneal epithelial macrocysts, small conjunctival hemorrhages, and cornea verticillata(20%) which resolve on discontinuation.
latanoprost
Generally less hyperemia, less pigmentation of iris, periorbital tissue (eyelid), and eye- lashes than Lumigan. Possible cystoid macular edema in pseudophakes and aphakes. May exacerbated iritis/uveitis. Possible reactivation of herpes simplex and zoster. Dry eye-like surface inflammation observed in mice.1 Avoid with inflammatory glaucomas and surface eye disease. |
| Pediatric use | Safety and effectiveness in pediatric patients have not been established. Latanoprost has been used in children as young as 5 yrs without notable problems.2 |
| Pregnancy | Category C. Embryofetal lethality in rabbits at 80x the normal human dose but not at 15x. |
| 0.015% BAK may be absorbed by contact lenses. Contact lenses should be removed prior to administration of the solution. Lenses may be reinserted 15 minutes following administration. |
2. Younus M, et al. Am J Ophthalmol. 2018;doi:10.1016/j.ajo.2018.08.039. N.L.M. DailyMed page for Pilocarpine