| Septra DS (U.S.N.L.M.) | |
|---|---|
| Dosing | Mild/Moderate: 1 single strength tab(400mg/80mg) q12hr, 10-14 days. Acute/Severe: 1 DS tab(800mg/160mg) q12hr, 10-14 days. |
| Chem Specs | sulfamethoxazole / trimethoprim |
| Quantities | DS = 800mg sulfamethoxazole/160mg trimethoprim, (low strength also available 400mg/80mg) |
| Cost | 16.93 / 20 tab generic |
| Class | Sulfonamide / Polypeptide (Pyrimidine (DHFR inhibitor)) |
| Action | Sulfonamides inhibit bacterial folate synthesis. Trimethoprim is a DHFR* inhibitor so inhibits bacterial DNA synthesis. |
| Usage | Used for soft tissue infections: hordeolum, preseptal cellulitis, dacryocystitis and dacryoadenitis. |
| Used when Penicillin allergy is known or suspected, for infections resistant to other medications, when MRSA is suspected and for health care personel. |
|
| Contraindications | Allergy to sulfamethoxazole, trimethoprim, or any sulfonamide. Severe liver or kidney disease. |
| Pediatric use | Contraindicated in children less than two months of age. Consult dosing tables (package insert ) and warnings for children under 40kg. |
| Pregnancy | Category C (N.I.H.) Teratogenicity demonstrated in rats in some studies. Increased risk of spontaneous abortion suggested in one large human study. (Also avoid use with nursing mothers) |
| Also labeled Bactrim and Sulfatrim. May increase risk of Stevens Johnson Syndrome. |