Tim-Latâ„¢ PF  (U.S.N.L.M.)
Dosing qpm
Chem Specs timolol 0.5%,    latanoprost 0.005%
Quantities 5ml,
Cost 108.00
Class     timolol:           Non-selective beta-adrenergic receptor blocker.
    latanoprost:    Prostaglandin analog (prodrug)
Usage Preservative-free, single container preparation can reduce surface toxicity and
enhance compliance. Requires refrigeration.

Bronchial asthma, a history of bronchial asthma, COPD, sinus bradycardia,
second or third degree atrioventricular block, overt cardiac failure, cardiogenic shock.
Use caution when cerebrovascular insufficiency is suspected.


Latanoprost hypersensitivity
Side Effects

Many side effects are associated with the vascular effects of beta blocking agents.
See a list here.


Generally less hyperemia, less pigmentation of iris, and lids than Lumigan.
Possible cystoid macular edema in pseudophakes and/or aphakes. May exacerbated
iritis/uveitis. Possible reactivation of herpes simplex and zoster. Dry eye-like surface
inflammation observed in mice.1 Avoid with inflammatory glaucomas and surface eye disease.
Pediatric use Safety and effectiveness in pediatric patients have not been established.
Latanoprost has been used in children as young as 5 yrs without notable problems.2
Pregnancy Category C   Embryofetal lethality shown in rats and rabbits at clinically relevant doses.
Bottle with one way valve requires Refrigeration.
Individual drugs are FDA approved but the combination is not.
1. Yang Y, et al. Invest Ophthalmol Vis Sci. July 2018, Vol.59, 3375-3384
2. Younus M, et al. Am J Ophthalmol. 2018;doi:10.1016/j.ajo.2018.08.039.