| Timoptic (U.S.N.L.M.) | |
|---|---|
| Dosing | Initial: 1 drop 0.25% bid; monitor and adjust. 1 drop qAM 0.25% or 0.50% is common. |
| Chem Specs | timolol maleate 0.25, 0.5% |
| Quantities | 5, 10, 15ml, 0.2 mL unit doses. |
| Cost | 31.97 / 5ml generic |
| Class | Non-selective beta-adrenergic receptor blocker. |
| Action | Reduces aqueous formation by blocking beta2 receptors on nonpigmented ciliary epithelium. |
| Usage | Common adjunct to prostaglandin therapy. Indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Usually result is 25% IOP reduction |
| 10 to 20% do not respond adequately to beta-blockers. Use in normal tension glaucoma remains questionable. |
|
| Contraindications | Bronchial asthma, a history of bronchial asthma, COPD, sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, cardiogenic shock or hypersensitivity to any component of the product. |
| Pediatric use | Safety and effectiveness in pediatric patients have not been established. |
| Pregnancy | Category C. Increased fetal resorptions in rabbits at doses of 14,000 times the maximum human dose. |
| Available as preservative free 0.2 mL "Ocudose" unit doses, otherwise BAK preserved. |
|
| Common U.S. brand name Istalol. (B&L) Timolol hemihydrate (Betimol $133.00) demonstated to have the same efficacy as the maleate form. |