| Tryptyr (U.S.N.L.M.) | |
|---|---|
| Dosing | 1gt each eye twice daily approximately 12 hours apart. |
| Chem Specs | 0.003% acoltremon solution |
| Quantities | 60 vials / carton. (12 foil pouches of 5 vials each). |
| Cost | $918.00 per carton |
| Class | TRPM8 thermoreceptor channel agonist. |
| Action | Increases basal tear production by activating trigeminal nerve signaling. |
| Usage | Indicated for the treatment of the signs and symptoms of dry eye disease. |
| 50% site pain on instillation. | |
| Contraindications | None |
| Pediatric use | Safety and efficacy of Tryptyr in pediatric patients have not been established. |
| Pregnancy | No adequate and well-controlled studies on Tryptyr in pregnant women. Acoltremon injected at 2151x the maximum recommended human dose in pregnant rabbits and rats resulted in no fetal toxicity. |
| 42% to 53% achieve ≥ 10 mm increase in Schirmer score from baseline. Use within 30 days after opening if stored at room temperature. |