Fortified Vancomycin   (U.S.N.L.M.)
Dosing/ Keratitis Every 30 minutes for 3 hours, then qhr for first 24 hours, taper gradually on improvement.
(If non central consider besifloxacin .)
Chem Specs vancomycin 5%
Quantities 500mg powder (reconstitute with 10ml sterile water)
Cost 866.38 / 500mg vial
Class Glycopeptide
Action Binds to amino acids necessary for bacterial cell wall synthesis and alters
bacterial cell membrane permeability.
Activity Narrow spectrum antibiotic. Bactericidal against certain gram-positive
organisms. Not active against gram-negative bacilli, mycobacteria, or fungi.
Usage Indicated for the treatment of serious or severe infections caused by susceptible
strains of methicillin-resistant staphylococci (MRSA) and penicillin-resistant streptococci.
Contraindications Known hypersensitivity to vancomycin.
Pediatric use Systemically used in infants > 7 days.
Pregnancy No adequate and well-controlled studies in pregnant women. Animal reproduction studies
have not been conducted with vancomycin.
The aqueous solution is unstable but may be kept refrigerated for 4 days (96hr).
When reconstituted may be labeled as 50 mg/ml vancomycin solution.
Consider concomitant cycloplegia for anterior uveitis. Fortified Vancomycin is used for gram-negative coverage.
5% solution stings on administration. Some advocate 2.5% which is thought to be adequate.1

1. Romanowski EG, Romanowski JE, Shanks RMQ, et al. Cornea. October 24, 2019.

    N.L.M. DailyMed page for Vancomycin         PDR page for Vancomycin