Doxycycline    (Vibramycin)   (U.S.N.L.M.)
Dosing:   (Meibomian gland disease.) Typical:      20mg - 50mg BID for 4 weeks then QD for another 4 to 8 weeks.
(Consider Azithromycin instead.)
Dosing:  (Adult Inclusion Conjunctivitis) 100mg BID X 7 days.   Consider Zmax.
Dosing:   (Recurrent Corneal Erosion) 50 to 100mg BID for 8 to 12 wks.
Chem Specs doxycycline
Quantities 20mg tablets,   100mg tablets and capsules
Cost 41.19 / 20 / 100mg    generic
Class Broad-spectrum, long acting tetracycline.
Action Inhibits protein synthesis, binding to the 30s ribosomal subunit of the mRNA. Inhibits production
of metalloproteinases and other cytokines. May inhibit production of bacterial lipases.
Usage Indicated in the treatment of inclusion conjunctivitis / trachoma and many other conditions
with susceptible organisms. Often used in the treatment of blepharitis (meibomianitis),
ocular rosacea, and recurrent corneal erosions.
Warnings Phototoxicity (exaggerated sunburn reaction, skin pigment changes), yeast infections,
increased intracranial pressure, and decreased effectiveness of birth control may occur.
Dental discoloration has been reported in adults.
Contraindications Hypersensitivity to any of the tetracyclines.
Use with caution even in non-pregnant women of childbearing years.
(Consider Cephalexin).
Pediatric use Enamel hypoplasia and discoloration in children to age 8 and in the last half of pregnancy.
Pregnancy Category D (Known risk to developing fetus.)
Use caution with concurrent Coumadmadin usage. Clostridium difficile associated diarrhea
has been reported with nearly all antibacterial agents. Resistance is very common.
    N.L.M. DailyMed page for Doxycycline          PDR page for Doxycycline