| Doxycycline (Vibramycin) (U.S.N.L.M.) | |
|---|---|
| Dosing: (Meibomian gland disease.) | Typical: 20mg - 50mg BID for 4 weeks then QD for another 4 to 8 weeks. (Consider Azithromycin instead.) |
| Dosing: (Adult Inclusion Conjunctivitis) | 100mg BID X 7 days. Consider Zmax. |
| Dosing: (Recurrent Corneal Erosion) | 50 to 100mg BID for 8 to 12 wks. |
| Chem Specs | doxycycline |
| Quantities | 20mg tablets, 100mg tablets and capsules |
| Cost | 41.19 / 20 / 100mg generic |
| Class | Broad-spectrum, long acting tetracycline. |
| Action | Inhibits protein synthesis, binding to the 30s ribosomal subunit of the mRNA. Inhibits production of metalloproteinases and other cytokines. May inhibit production of bacterial lipases. |
| Usage | Indicated in the treatment of inclusion conjunctivitis / trachoma and many other conditions with susceptible organisms. Often used in the treatment of blepharitis (meibomianitis), ocular rosacea, and recurrent corneal erosions. |
| Warnings | Phototoxicity (exaggerated sunburn reaction, skin pigment changes), yeast infections, increased intracranial pressure, and decreased effectiveness of birth control may occur. Dental discoloration has been reported in adults. |
| Contraindications | Hypersensitivity to any of the tetracyclines. Use with caution even in non-pregnant women of childbearing years. (Consider Cephalexin). |
| Pediatric use | Enamel hypoplasia and discoloration in children to age 8 and in the last half of pregnancy. |
| Pregnancy | Category D (Known risk to developing fetus.) |
| Use caution with concurrent Coumadmadin usage. Clostridium difficile associated diarrhea has been reported with nearly all antibacterial agents. Resistance is very common. |