| Zirgan (U.S.N.L.M.) | |
|---|---|
| Dosing/ Herpes Simplex | 1 gt 5 times per day (q3hr while awake) until the corneal ulcer heals, then 1 drop 3 times per day for 7 days. |
| Chem Specs | 0.15% ganciclovir gel |
| Quantities | 5 gm tube |
| Cost | 463.00 / 5 gm tube |
| Class | Ganciclovir is a guanine analogue. |
| Action | Activated form inhibits viral DNA synthesis. |
| Activity | Ganciclovir is active against most species in the herpesvirus family. |
| Usage | Indicated for the treatment of acute herpetic keratitis (dendritic ulcers). (Two thirds of early Acanthamoeba keratitis are misdiagnosed as HSV.) |
| Contraindications | Hypersensitivity to Ganciclovir or any included ingredients. |
| Pediatric use | > 2 years |
| Pregnancy | No adequate and well-controlled studies in pregnant women. Teratogenic in animals when 10,000 to 17,000 times the human ophthalmic dose is administered. No adequate and well-controlled studies in pregnant women. Teratogenic in animals when 10,000 to 17,000 times the human ophthalmic dose is administered. |
| 0.0075% BAK preserved. Does not require refrigeration. |